Dimethyl fumarate associated lymphopenia in clinical practice
نویسندگان
چکیده
منابع مشابه
Dimethyl fumarate-associated lymphopenia: Risk factors and clinical significance
BACKGROUND Dimethyl fumarate (DMF), a disease-modifying therapy for multiple sclerosis (MS), causes lymphopenia in a fraction of patients. The clinical significance of this is unknown. Several cases of progressive multifocal leukoencephalopathy in lymphopenic fumarate-treated patients have raised concerns about drug safety. Since lymphocytes contribute to MS pathology, lymphopenia may also be a...
متن کاملCharacterization of lymphopenia in patients with MS treated with dimethyl fumarate and fingolimod
[This corrects the article on p. e432 in vol. 5, PMID: 29296636.].
متن کاملDimethyl fumarate–induced lymphopenia in MS due to differential T-cell subset apoptosis
OBJECTIVE To examine the mechanism underlying the preferential CD8+ vs CD4+ T-cell lymphopenia induced by dimethyl fumarate (DMF) treatment of MS. METHODS Total lymphocyte counts and comprehensive T-cell subset analyses were performed in high-quality samples obtained from patients with MS prior to and serially following DMF treatment initiation. Random coefficient mixed-effects analysis was u...
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In a series of proof-of-concept experiments using in vitro and in vivo models of ischemic stroke, we provide evidence that dimethyl fumarate (DMF) strongly reduces neuronal cell death upon ischemic insult through pleiotropic anti-inflammatory and cytoprotective effects [1, 2]. DMF is a derivative of the fumaric acid, an intermediate product of the citric acid cycle. DMF is marketed as Tecfidera...
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Background: Dosimetry is a fundamental part of the radiation processing industry. Aqueous inorganic dosimeters have been used for gamma radiation dosimetry such as standard ferrous sulfate dosimeter. The purpose of this study was to investigate the effect of gamma radiation on the diethyl fumarate DEF in dimethyl sulfoxide DMSO solution and its possible use in chemical dosimetry. Materials and ...
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ژورنال
عنوان ژورنال: Multiple Sclerosis Journal
سال: 2014
ISSN: 1352-4585,1477-0970
DOI: 10.1177/1352458514559299